CV Lattes
Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (2009). (Source: Lattes Curriculum)
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The acute lymphoid leukemias (ALL) are widely associated with chromosomal abnormalities and recurrent genetic mutations. A recent study describes the occurrence of mutations in exon 6 of the IL-7 receptor (IL7Ra) alpha chain gene in 9% of the T phenotype ALL (ALL-T). In most cases (80%), IL7Ra mutations resulted in insertion of a cysteine in the extracellular portion juxtaposed to the tra…
IL-7Ra is a transmembrane receptor that lacks kinase activity. Signal transduction by the IL-7R± is dependent on the associated protein tyrosine kinase JAK1 (Janus kinase 1), anchored to the intracellular domain of the receptor. IL-7R± forms a heterodimer with the gamma chain transmembrane receptor, which brings JAK3. Signaling occurs only in presence of IL-7, when JAK1 and JAK3 trans-pho…
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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