graduate at Odontologia from Faculdade de Odontologia de Ribeirão Preto Usp (1996), master's at Odontopediatria Ribeirão Preto from Universidade de São Paulo (2001) and ph.d. at Patologia Experimental from Faculdade de Medicina de Ribeirão Preto Usp (2007). Has experience in Odontology, focusing on Odontopaediatrics, acting on the following subjects: dentes permanentes, escovas dentais, desinfecção, dentes decíduos and pulpotomia. (Source: Lattes Curriculum)
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Cathepsins, a group of cysteine proteases, play an important role in some pathological processes. It is known that an increase in their activity, especially cathepsin K, is related to the development of diseases, such as osteoporosis and apical periodontitis (periapical lesion), because they stimulate the bone resorption process. Therefore, its inhibition could be a therapeutic target for…
Cathepsins are enzymes that participate in the process of bone resorption by proteolytic degradation of the matrix components, and that, in disorder, lead to the development of some pathological conditions as osteoporosis, periodontitis, apical periodontitis (periapical lesion), among others. In this context, it is known that the use of cathepsin inhibitors, known as cystatins, can contro…
Recently peracetic acid (PA) has been reported in the dental literature as a possible root canal irrigating solution. It has the advantage of bringing together in one product antibacterial activity and ability to remove smear layer. For the selection of root canal irrigating solution it should take into account not only its therapeutic benefits, but also the possible cytotoxic effects, si…
Recently an alternative technique has been recommended for the treatment of teeth with incomplete root formation and pulp necrosis. A triantibiotic paste (TP) consisting of ciprofloxacin, metronidazole and minocycline is used for disinfecting root canal system followed by the induction of bleeding to fill the root canal and the coronal sealing. This technique allows root canal revasculari…
Cathepsins, a group of cysteine proteases, play an important role in some pathological processes. It is known that an increase in their activity, especially cathepsin K, is related to the development of diseases such as osteoporosis and apical periodontitis, as they participate in the bone resorption process. Cystatins are natural and reversible inhibitors of cysteine proteases. The cysta…
Apical Periodontitis (AP) is characterized by the presence of inflammation and destruction of mineralized and non-mineralized periapical tissues, processes that involve the production of cytokines, osteoclastogenesis and the action of enzymes, including cathepsin K (CatK). Tanshinones, substances extracted from the plant Salvia miltiorrhiza, are widely used in traditional Chinese Medicine…
Cathepsins (a group of cysteine-proteases) play an important role in some pathological processes. It is known that an increase in their activity is related to the development of diseases such as osteoporosis and apical periodontitis (periapical lesion), as they stimulate the bone resorption process, through the proteolytic degradation of matrix components. Therefore, its inhibition could …
Results published by our research group showed that cystatin CsinCPI-2, derived from citrus sinensis (sweet orange), was able to inhibit the gene expression and enzymatic activity of human cysteine cathepsins, showed anti-inflammatory activity and, had pro-osteogenic effect on human dental pulp cells. This pro-osteogenic effect was demonstrated by the increase in the alkaline phosphatase …
The zinc oxide and eugenol cement (ZOE) and calcium hydroxide paste thickened with zinc oxide are the most frequently used materials for root canal filling of primary teeth. Recently a new bioceramic material for root canal filling of primary teeth, BIO-C Pulpecto (Angelus, Londrina, Paraná, Brazil) has been developed. The aim of this study will be to evaluate the biological properties of…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 11 / 10 | Completed scholarships in Brazil |
| 17 / 16 | All research grants and scholarships |
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CV Lattes
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