Raquel F Gerlach is a DDS that has a Master's Degree in Oral Biology from the Universidade Estadual de Campinas (1998), and a PhD in Cell Biology from Universidade Estadual de Campinas (2000). Has experience in Cell and Molecular Biology, acting on the following subjects: MMP-9, MMP-2, dental enamel, gelatinases and the use of teeth as biomarkers of exposure to both essential and toxic metals, particularly lead (Pb), chronic inflammatory diseases and MMPs. Dr Gerlach's studies on the recovery of enamel-specific peptides resulted in the wide-spread use of enamel peptides to characterize the biological sex of ancient individuals and the use of enamel proteome to set new species of animals (including a new human) based on the enamel peptide sequences in a time (> 1 million years) when DNA is not adequate for analyses anymore. E-mail: rfgerlach@forp.usp.brPhone: +55-16-3602-4065 (Source: Lattes Curriculum)
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The role of Matrix Metalloproteinases (MMPs) in the degradation and extracellular matrix remodeling is but one aspect of the role played by this family of proteases that has 27 members. Once activated, the MMPs cleave cleave substrates such as matrix proteins, proinflammatory mediators, and growth factors, which will activate several signalling passways that depend on MAP kinases, and are…
Atherosclerosis is a major cause of morbidity and mortality worldwide. The chemokine CCL2/MCP-1 (monocyte chemotactic protein-1) is considered responsible for the recruitment of monocytes and macrophage differentiation. Matrix metalloproteinase-2 (MMP-2) is associated with the development of atherosclerotic thrombi and their destabilization. However, there is an important controversy in t…
The regulation of matrix metalloproteinases (MMP) has been studied due to the fundamental roles these zinc-endopeptidases play in diverse physiological and pathological processes. Phosphorilation is the mainly posttranslational modification in eukaryonts and has been described in recombinant MMP-2 from hamster ovarian cells and in MMP-2 from HT1080 cell-conditioned medium supernatant. The…
(Only some records are available in English at this moment)
Molar incisor hypomineralization (MIH), also known as "chalky teeth" or "calcareous teeth", is a developmental defect of the enamel that happens during the maturation stage. Teeth with MIH are already found in one out of five children, generating social and financial burdens worldwide. MIH is recognized worldwide as a public health problem. Latin America is the most affected continent. Th…
The molar incisor hypomineralization (MIH), also known as "chalk teeth" or "calcareous teeth", is a developmental defect of the enamel that happens during the maturation stage. Teeth with MIH are already found in one out of five children, generating social and financial burdens worldwide. MIH is recognized worldwide as a public health problem. Latin America is the most affected conti…
Dental enamel and dentin have very variable concentrations of the different chemical elements, and the concentrations also vary in different parts of the enamel and at different depths of the dentin. Currently, these variations are not taken into account when measuring microelements in teeth, and this is one of the most important factors for having very discrepant data on microelements in…
The role of matrix metalloproteinases (MMPs) in the degradation and extracellular matrix remodeling is but one aspect of the role played by this family of proteases that has 27 members. Once activated, the MMPs cleave substrates such as matrix proteins, proinflammatory mediators, and growth factors, which will activate several signaling passways that depend on MAP kinases, and are importa…
(Only some records are available in English at this moment)
Eventhough a marked decrease in caries prevalence has been observed worldwide, there are still groups of people with high caries prevalence. A few recent studies show associations between genetic polymorphisms and caries, and what is particularly relevant: in genes that may have a plausible biological association with dental caries. However, concentrations of Ca, P and F, and the quantifi…
| 13 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 41 / 19 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 58 / 28 | All research grants and scholarships |
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