Bachelor of Science in Molecular Sciences (2010) and in Biological Sciences (2013) at University of São Paulo. Master of Sciences in Immunology also at University of São Paulo (2013). After an internship at the Heart Institute (Incor), she obtained her PhD at KU Leuven (Belgium) in 2021. Currently, she is a postdoctoral fellow in the DNA Repair laboratory at the University of São Paulo. (Source: Lattes Curriculum)
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Individuals with Xeroderma Pigmentosum (XP), a rare autosomal genetic disease, present defects to repair DNA lesions induced by ultraviolet radiation (UV). As a consequence, XP patients are extremely sun sensitive and they have increased risk to develop Skin Cancer compared to the general population. A recent study has shown that UVA-irradiated XP variant (XP-V) cells present a slower DNA…
During terminal differentiation of B lymphocytes into plasma cells, the latter cells demand for increased levels of immunoglobulin synthesis. To accommodate the immunoglobulin overload, an expansion of the endoplasmic reticulum (ER) occurs. This causes stress in the ER, activating an intracellular signaling pathway named Unfolded Protein Response (UPR), pathway of which BiP is part of it.…
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