CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Antonio José da Costa Filho received a Bachelor degree in Physics from the University of São Paulo (USP) in 1994. After that he started his Graduate program in the same university, concluding his Masters in 1996. His PhD project was developed both in São Carlos, under the supervision of Prof. Otaciro Nascimento, and in Ithaca (USA), where he spent 3 years as a visiting graduate student at Cornell University, working under Prof. Jack Freed´s supervision. During his PhD, Prof. Antonio Costa worked on the development of new electron magnetic resonance methods for the study of: (1) lipid-protein interactions, (2) the dynamic structure of lipid membranes, and (3) metal centers in protein structure. In 2001 he received his PhD degree in Physics from the University of São Paulo and started working as an Assistant Professor at USP (Campus São Carlos). He is currently Full Professor at USP-Ribeirão Preto and his research interests involve the investigation of interactions between biomolecules with emphasis on how the interaction between proteins and their ligands (substrates, inhibitors, and membranes) can lead to modulation of the protein function. More recently, he also got interested in the structural behavior of proteins involved in the unconventional secretory pathways of the cell, in particular the so-called Golgi Reassembly and Stacking Proteins (GRASPs). To accomplish those objectives his group makes use of a combined and interdisciplinary approach of experimental techniques, such as magnetic resonance, circular dichroism, and microcalorimetry. He has received several awards for his teaching skills as well as for contributions to his specific field of scientific interest. He is a Young Affiliate Alumnus of the Brazilian Academy of Sciences and of the World Academy of Sciences, former member and coordinator of the Advisory Committee of the Brazilian National Science Foundation (CNPq) on Biophysics/Biochemistry/Physiology/Pharmacology/Neurosciences, current President of the Brazilian Biophysical Society, and director of the Ribeirão Preto Institute for Advanced Studies of the University of São Paulo. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Low complexity domains (LCDs) are sequences of amino acids with very peculiar structural features and still poorly explored in Biochemistry and Molecular Biophysics. Their dynamics of interactions as well as their functions, toxicity and persistence during evolution still lack better understanding. It is known, tough, that if used as molecular adhesives in proteins (so called- chimeras), …
(Only some records are available in English at this moment)
The Golgi Reassembly And Stacking Proteins (GRASPs) are involved in a series of functions, both in unconventional secretion mechanisms and in the structuration and organization of the Golgi apparatus. However, understanding their exact role in each situation still needs more structural and functional results at the molecular level. In performing such functions, GRASPs always seem to be so…
Photodynamic Therapy (PDT) has gained relevance due to its applications in cancer treatments and has now stood out for its variety of applications, such as in the fight against neoplastic diseases, inflammatory diseases, microbial infections and the fight against aging. PDT is a technique based on the use of three essential components: light, a photosensitizing molecule and oxygen. When e…
(Only some records are available in English at this moment)
The discovery and development of phototoxic proteins able to produce reactive oxygen species allowed the employment of genetically encoded photosensitizers (PS) as light activated devices. Light-induced generation of reactive oxygen species by chromogenic compounds has been used for single molecule inactivation and cell killing. MiniSOG is a small, soluble, flavin-binding protein with hig…
Eukaryotic cells have a complex and regulated secretory system that can deal with up to 30% of the total proteome. A subfamily of the Golgi matrix proteins called Golgi Reassembly and Stacking Proteins (GRASP), which are critical players in the unconventional, stress-induced, secretory pathway (UPS), was also shown to be fundamental for the Golgi dynamics during mitosis/apoptosis and Golg…
Alkaline phosphatases are a class of enzymes that catalyze the hydrolysis of phosphomonoesters, thus producing phosphate. In humans, four alkaline phosphatases have been identified so far. In mammals, this enzyme can be associated to genetic disorders leading to different levels of bone failure and pathological blood vessel mineralization. Due to its biological relevance, tissue non-speci…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 13 / 9 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 37 / 27 | Completed scholarships in Brazil |
| 8 / 8 | Completed scholarships abroad |
| 62 / 48 | All research grants and scholarships |
| Associated processes | |