Abstract
Several studies have shown that chondrocyte aging is associated with the degeneration of articular cartilage, and can be observed in joint diseases pathogenesis, such as rheumatoid arthritis and osteoarthritis (OA). One of the most prominent changes in cartilage is related to extracellular matrix components. Moreover, pro-inflammatory cytokines, such as TNF-alpha and IL-1², play pivotal r…