bachelor's at Ciências Biológicas from Instituto de Biociências da USP (2007), master's at Histology from Universidade de São Paulo (2010) and doctorate at Histology from Universidade de São Paulo (2014). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: microrna, cancer de tiróide, tiróide, iodo and mir-17-92. (Source: Lattes Curriculum)
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Metastasis is the main cause of cancer-related death, however the progress of molecular understanding did not correspond to the urgency of this disease. Thus, the investigation of new transcriptional and posttranscriptional molecular alterations is mandatory for understanding tumor heterogeneity beyond genomics. In this context, changes in miRNA expression can act as potent post-transcrip…
Anaplastic thyroid carcinoma (ATC) is the most aggressive and fatal endocrine cancer. Due to the loss of thyroid cell differentiation, ATC does not uptake iodine, and thus, is refractory to radioiodine therapy. The molecular pathways altered in ATC pathogenesis are associated to mutations in MAPK, inactivation of TP53 and mutations in TERT promoter. However, additional alterations may con…
The polycomb complex PRC2/EZH2 is an epigenetic modulator that represses gene expression by trimethylation of histone H3 at lysine 27 (H3K27Me3). In cancer, several studies have reported increased EZH2 expression, especially in aggressive types of cancer. Our previous data show and the literature showed that EZH2 levels are increase in anaplastic thyroid cancer (ATC), the most lethal form…
Lung cancer is the second most common type of cancer and the main cause of cancer-related death worldwide. The high mortality is associated to late detection of the disease when most of patients already display distant metastases, reducing the overall 5-year survival to 20%.The main oncogenic pathway is MAPK with mutations in KRAS and EGFR, and high prevalence of inactivating mutations in…
The polycomb complex PRC2/EZH2 is activated in aggressive cancer and induces gene silencing through histone modifications and chromatin accessibility. However, the mechanism underlying the activation of EZH2 gene expression in thyroid cancer is under investigation. In this context, the molecular investigation of the promoter region of EZH2 could contribute to the identification of transcr…
The increase in PRC2/EZH2 Polycom complex activity in aggressive cancer induces gene silencing through histone modifications and chromatin accessibility. However, the mechanism underlying the targeting of PRC2/EZH2 to specific regions of the genome is under investigation. In this context, long noncoding RNAs emerge as potential mediators as they can recruit and Interact with PRC2/EZH2. Cl…
Anaplastic thyroid carcinoma (ATC) is the most aggressive and fatal endocrine cancer. Due to the loss of thyroid cell differentiation, ATC does not uptake iodine, and thus, is refractory to radioiodine therapy. The molecular pathways altered in ATC pathogenesis are associated to mutations in MAPK, inactivation of TP53 and mutations in TERT promoter. However, additional alterations may con…
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miRNA deregulation is an important step in oncogenesis associated with activation of oncogenic pathway and inhibition of tumor-suppressor genes. During tumor progression, a complex network of miRNAs and its targets are modulated which is likely to contribute to metastatic phenotype and tumor spreading. Metastases are the main cause of cancer-related death, particularly lung cancer, which …
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 6 / 4 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 10 | All research grants and scholarships |
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CV Lattes
ORCID