CV Lattes
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Biologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1972), master's at Physiology from Universidade de São Paulo (1975) and ph.d. at Physiology from Universidade de São Paulo (1977). He is currently full professor at Universidade de São Paulo. Has experience in Physiology, focusing on General Physiology, acting on the following subjects: patch clamp, eletrofisiologia, electrophysiology, leydig and leydig cell. (Source: Lattes Curriculum)
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The role played by Nitric Oxide (NO) as a neurotransmitter in controlling the electrical activity of Magnocellular Neurons of the SON (MNCs) was postulated after reports that hyperosmotic stimulation of these cells lead to an increase in the expression of nitric oxide synthase (NOS) mRNA and of oxytocin (OT) and vasopressin (VP) secretions. Several reports show that NO can act both indire…
This project is concerned with ion transport in Leydig cells aiming at an understanding of the role played by specific receptors and ionic currents in the physiological processes carried out by those cells. On one side, the project is devoted to an analysis of the cellular handling of calcium ions concerned with its spacial distribution and its role in steroidogenesis. On the other side, …
This project is concerned with ion transport in Leydig cells and in cells of neural tissue (supra optic nucleus) aiming at an understanding of the role played by specific receptors and ionic currents in the physiological processes carried out by these cells. Although both cells are involved in secretor processes, testosterone in one case and ADH in the other, we intend to use the patch cl…
(Only some records are available in English at this moment)
The importance of Nitric oxide (NO) as a neurotransmitter acting on magnocellular neurons of the supraoptic nucleus (nmSON) became evident when the expression of nitric oxide synthase (NOS), oxytocin (OT) and vasopresin (VP) RNAm levels were increased by treating the cells with hyperosmotic solution. Currently, it is well known that NO has an indirect effect on the nmSON activity by acti…
Leydig cells are the main site of production and secretion of testosterone in males. Its synthesis is mainly controlled by the Luteinizing Hormone (LH) whose action on membrane receptors leads to an increase in both cAMP and intracellular calcium concentrations. As a result, the expression of STAR (Steroidogenic Acute Regulatory protein), an essential protein involved in the transport of …
In recent years, a large amount of studies is dedicated to understand the role of ATP as an intercellular signaling agent. Several evidences confirm its function as a mediator and/or modulator of both fast events, like the neurotransmission, as well as of long term cellular processes, involving G proteins. ATP acts on the plasma membrane by interacting with purinergic receptors P2X (ligan…
| 15 / 5 | Completed research grants |
| 10 / 3 | Completed scholarships in Brazil |
| 25 / 8 | All research grants and scholarships |
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