Luiz Fernando da Silva Júnior

• Abstract

  Our research group started to investigate reactions promoted by hypervalent iodine in 2005. Initially, only ring contractions were studied. However, other transformations, such as, electrophilic cyclizations and alkynylations were gradually incorporated into the group repertory. Many challenges still remain and this projects aims to develop further reaction mediated by hypervalent iodine,…

  Hypervalent iodine: methodology and total synthesis, AP.R

• Abstract

  Cyclic compounds are an important moiety in most of the natural products. Moreover, all top selling drugs that are small organic molecules possess at least one ring in its structure.. In this project we plan to synthesize several kinds of cyclic compounds using as tool iodine, either in the form of the classic moleculas iodine or in the modern version of the hypervalent iodine compounds. …

  Hypervalent iodine in the synthesis of cyclic compounds: development of reactions and total synthesis of natural products, AP.R

• Abstract

  Biocatalysis has been established as a powerful tool in organic synthesis. The enzyme-catalyzed reactions mostly distinguished by their high chemo-, regio- and stereo-selectivity. In this project we will present different topics related to the use of enzymatic reactions in organic synthesis. We will study the application of enzymatic reactions involving organic compounds containing hetero…

  Enzymatic reactions: exploiting your potential as synthetic tool, AP.R

(Only some records are available in English at this moment)

• Abstract

  A proposal for the asymmetric synthesis of (+)-cis-trikentrin in 12 steps from commercially available acetophenone will be shown in this project. Important reactions on the suggested route involve enzymatic resolution and a Friedel-Crafts intramolecular acylation. The reported asymmetric syntheses until now present 14 and 17 steps, i.e., the proposed route is shorter and will enable new a…

  Total synthesis of (+)-cis-Trikentrin A, BP.MS

• Abstract

  Alkaloids bearing the indole moiety constitute one of the most important groups of natural products, mainly due to their remarkable biological activity. Usually, these heterocyclic compounds are substituted in the very reactive two and three positions. In 2010, raputindoles A-D were isolated from the Amazonian plant Raputia simulans Kallunki (Rutaceae), which was collected in Peru. In 201…

  Synthesis and application in alkynylation of southwest fragment of raputindol A and D, BP.IC

• Abstract

  This projects aims to advance in the synthesis of different cyclic compounds through an iodine (III)-mediated ring contraction reaction. The success of this project will allow a new approach toward the synthesis of 2-substituted indanes, which will be used in a novel route to Donepezil.

  Ring contraction of 1,4-Dihydronaphthalenes and the synthesis of Donepezil, BP.IC

(Only some records are available in English at this moment)