Abstract
Obesity-induced chronic inflammation is associated with macrophages migration to adipose tissue, which produce proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)- 1 e IL-6, contributing to type 2 diabetes mellitus and metabolic syndrome pathogenesis. In macrophages, the modulation of gene expression of many cytokines involved in inflammatory processes i…