Abstract
Paracoccidioidomycosis (PCM), a relevant systemic mycosis in Latin America, is caused by Paraccoccidioides brasiliensis (Pb). The innate immunity in PCM is poorly understood but our recent studies in the murine model of PCM have demonstrated the important role of indoleamine 2,3-dioxygenase (IDO), an enzyme that controls fungal burdens but also suppresses the innate and adaptive immune re…