Mariane Tami Amano

• 8th International Symposium on Inflammatory Diseases - INFLAMMA VIII, AO.R
• European congress of immunology, AR.EXT

• Abstract

  Macrophages are immune system cells that are found in all tissues and have phagocytosis as one of their main activities. These cells can have different activation phenotypes depending on the microenvironment composition they are in. An important receptor present in these cells is TLR4, which recognizes patterns such as LPS and other endogenous antigens. Agonists action in this pathway res…

  Investigation of cellular signaling pathways involved in macrophages tolerization in the tumor context, BP.MS

• Abstract

  Acute myeloid leukemia (AML) is a complex hematological cancer that mainly affects elderly patients (over 60 years old) and these patients are the ones that have worst response to current treatments. Thus, there is a great need for new therapeutic alternatives for this cancer. In the last decade, the BRD4 (bromodomain-containing protein 4) has been identified as one of the main possible t…

  The effect of the combination of BRD4 and mTOR pathway inhibitors on immune checkpoint co-receptors in acute myeloid Leukemia, BP.IC

• Abstract

  Acute myeloid leukemia (AML) is an aggressive disease and corresponds to the lower survival rate among leukemias types. Only 40% of the patients under 60 y.o. survive more than 5 years and, in patients over 60 y.o., the chemotherapy does not provide the cure and cause death in less than a year. Thus, revealing the urgent seek for new treatments. The BRD4 (Bromodomain-containing protein 4)…

  The effect of the combined treatment of BET inhibitors and signaling pathways on the induction of DNA damage in leukemic cells, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Cohesin is a multisubunit protein complex initially described to provide stability to sister chromatids during cell division. Recent studies have shown the occurrence of mutations in cohesin in adult myeloid leukemic cells, however, the mechanism of how cohesin could influence on leukemia development is still unclear. Similarly, in children, a high incidence of cohesin components mutation…

  The role of cohesin mutations in myeloid malignancies development, BE.EP.PD

• Abstract

  Macrophages are antigen-presenting cells (APCs) and are essential first responders that trigger innate immune responses leading to appropriate adaptive immune responses. They express Toll like receptors on their surface and it is this family of receptors that recognize pathogen associated molecular patterns (PAMPs) and activate the macrophage. Activated macrophages increase expression of …

  The influence of heme oxygenase-1 in mTOR pathway activation in macrophages, BE.EP.IC