Debora Amado Scerni

• Abstract

  Epilepsy affects about 1% to 2% of world population, and the mesial temporal lobe epilepsy (TLE) the most frequent, representing 40% of patients, these are often refractory to medicaI treatment. One of the most used tools to try to understand the pathophysiology of MTLE is induced animal models. Despite several animal models currently available and widely studied, most of these lesions pr…

  Multimodal investigation of epileptogenesis with emphasis in the implementation of new animal models and new tools, AP.TEM

• Abstract

  We aim at investigating different aspects of the epilepsies in humans ranging from electrophysiological and immunocitochemical investigations of surgically ressected tissue to the evalution of new therapeutic strategies to be used in the prophylaxis of post-lesional epilepsies. The proposed experiments will rely on magnetic resonance imaging and thus will attempt to provide correlations b…

  Temporal lobe epilepsy: a study correlating brain image, morphological features, electrophysiological findings, hormonal and neurochemical aspects in humans with and without mesial temporal sclerosis, AP.CINAPCE.TEM

• Abstract

  The epilepsy is very common in about 1% of population affecting man and women and it is a neurological disturb more frequent in the obstetric practice, occurring in 0.3 to 0.6% of pregnancies. These pregnancies are classified as high risk and present a major probability of complications, and the accompaniment of epileptic women that demonstrate desire of to become pregnant present three p…

  Effects of maternal epileptic seizures in the development of the offspring, AP.R

(Only some records are available in English at this moment)

• Abstract

  The neotropical wild rodent Proechimys guayannensis is a direct host of pathogens (Trypanosoma, Leishmania, cestodes, and larvae) but demonstrates innate resistance to these organisms. This rodent is of interest in Neuroscience due to scientific results that reveal an endogenous antiepileptogenic mechanism. However, its physiology is still poorly known and the work done with this animal i…

  Characterization of Proechimys estral cycle in the lithium-pilocarpine Epilepsy Model, BP.DD
• Resistance to pilocarpine-induced status epilepticus: assessment of hormonal mechanisms involved in epileptogenesis, BP.PD

• Abstract

  Mesial temporal lobe epilepsy represents for 60% of the temporal lobe epilepsies, and it is intensively studied because of its high incidence and its resistance to pharmacological treatment. This type of epilepsy is associated with hippocampal sclerosis, the most common epileptogenic lesion wich is characterized by neuronal loss, ectopic neurons, formation of amyloid bodies, dispersion of…

  Hormonal effects on signal transduction and angiogenesis in the neocortex and hippocampus in women with medial sclerosis epilepsy in the reproductive period, BP.PD

(Only some records are available in English at this moment)