Resumo
Mitochondria are the principal source of cellular energy which is produced by oxidative phosphorylation (OXPHOS) leading to the production of adenosine triphosphate (ATP). Thirteen essential OXPHOS proteins are synthesised within the mitochondrion from mitochondrial DNA (mtDNA) which is exclusively inherited down the maternal line. MtDNA is highly polymorphic in humans, but the single nuc…