Graduated in Dentistry at University of São Paulo (2001). Specialist in Endodontics at Hospital for Rehabilitation of Craniofacial Anomalies (2004). Master degree at University of São Paulo (Dental School of Bauru) at Endodontics. PhD at University of São Paulo in Oral Biology. Main research field: proinflammatory potential of oral fibroblasts. Additional research projects focusing on dental materials applied to Endodontics. (Source: Lattes Curriculum)
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Mineralized tissue resorption is a biological event present in challenging oral pathologies such as periodontal diseases, apical periodontitis and external root resorption. The role of mesenchymal cells at bone metabolism modulation is described, but not the role of apical papilla cells under this context, specially by means of osteoprotegerin (OPG) effect. The aim of this study is to inv…
The endodontic treatment of immature teeth is considered one of the greatest challenges of contemporary Endodontics. Despite the recent advances in this area of Dentistry, the molecular mechanisms involved with interruption of root formation resulting from dental caries or trauma are still unknown. Therefore, the aim of this study is to elucidate the role of inflammatory mediators in func…
Bone and root resorption are among the main responsible causes of tooth loss. Regenerative endodontic procedures have been recently proposed as an alternative for the treatment of external root resorption. Monocytes are the osteoclast precursor and they are considered key cells in this context. Stem cells of the apical papilla (SCAP) are in close contact with bone along root formation and…
The cells of apical papila (CPA) have direct influence in the root formation during dental development, acting as a source of dentin-synthesizing cells. If a pulpal pathological process is installed before the end of rhizogeneses, there is the possibility of pulpal necrosis and interruption of root formation. Although this cause/effect relationship is known, the molecular mechanisms invol…
Gutta-percha is stablished as root canal filling material due to its physical properties and biocompatibility. The addition of bioglass has being proposed in order to improve gutta-percha properties, however the biomodulation effect of bioglass containing-gutta-percha is still unknown. Taking this into consideration, this project aims to investigate the biomodulation of bioblass containin…
Teeth with open apices accomplished by pulp necrosis present important structure commitment with short roots and thin dentin walls. At the same time, the development of periapical bone resorption areas is observed. The scientific literature has demonstrated mechanisms involved with the production of mineralized matrix by apical papilla cells, however evidences regarding the capacity of th…
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The apical papilla has an important role in root formation during dental development, acting as a source of stem cells that differentiate into the putative dentin-synthesizing cells, odontoblasts. Pulpal inflammation on immature teeth, resulting from caries or trauma, might lead to necrosis and the interruption of root formation. Among the inflammatory mediators potentially involved in th…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 12 | All research grants and scholarships |
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CV Lattes
ORCID