CV Lattes
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ORCID
Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Biológicas e da Saúde (CCBS) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Graduate at Bacharelado em Bioquímica from Universidade Federal de Viçosa (2004) and master's at Bioquímica from Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP/USP) (2007) and pHD from FMRP/USP (2011). Has experience in Biochemistry, focusing on protein-protein interaction, proteomic, cellular and molecular biology and synthetic peptide synthesis. (Source: Lattes Curriculum)
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The ubiquitin proteasome system (UPS) is responsible for the most of intracellular proteolysis in eukaryotes and the ubiquitination process occurs through the action of three enzymes: E1 (ubiquitin-activating enzyme), E2 (ubiquitin-carrying enzyme) and E3 (ubiquitin-ligases) that play a key role in this process, recognizing and transferring ubiquitin to its substrate. These ubiquitinated …
Fbxo7 is one of the 69 human F-box proteins, which interacts with SKP, Cullin and RBX to form the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. In addition to the F-box domain of interaction with SKP1, the Fbxl17 contains the LRR domain (Leucine Rich Repeat) which interacts with its substrates. The FBXL17 gene is recurrently disrupted by rearrangements in the…
The CoC / CCBS, considering the specificities of the Areas (Biological and Health) that make up the academic, research and extension structure of CCBS / UFSCar, following the guidelines of FAPESP, guided the application of RTI-FAPESP resources from the diagnosis of the current situation, in which the necessary actions were established to overcome the identified difficulties and to improve…
Fbxo7 is one of the 69 human F-box proteins, which are the specificity factors for the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. Fbxo7 is a F-box only protein (Fbxo) of clinical importance having been associated with two major diseases, cancer and Parkinson's disease (PD). It regulates the cell cycle and it is expressed in tumors of epithelial lineages (c…
The Fbxl17 protein is one of 69 F-box proteins that interact, through their F-box domain, with the SKP1, Cullin 1 and RBX1 proteins to form the SCF complex, which is the largest class of human E3 ubiquitin ligases. These enzymes are responsible for their substrates ubiquitination for degradation by proteasome or for their cellular function modulation. In addition of F-box domain, FBXL pro…
Fbxo7 is one of the 69 human F-box proteins, which interacts with SKP, Cullin and RBX to form the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. In addition to the F-box domain of interaction with SKP1, the Fbxl17 contains the LRR domain (Leucine Rich Repeat) which interacts with its substrates. The FBXL17 gene is recurrently disrupted by rearrangements in the…
The Translocase of Outer Mitochondrial Membrane 20 (TOMM20) recognizes location signals of proteins that will be imported to the mitochondrial matrix, contributing to mitochondrial homeostasis. TOMM20 has also a major role in mitophagy pathway triggered by mitochondrial depolarization, blocking PINK1 importation and promoting its stabilization in mitochondrial outer membrane. Recently, ou…
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Fbxo7 is an unusual protein which has been found to be associated with two major human diseases, cancer and Parkinson's disease (PD). Fbxo7 is one of the 69 human F-box proteins that serve as specificity factors for the largest family of ubiquitin-ligases known as SCF-type E3 ubiquitin ligases. These modular, multi-subunited holoenzymes are composed of S-phase-kinase associated protein 1…
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 7 / 6 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 12 / 11 | All research grants and scholarships |
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