Abstract
The Anaphase-Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase involved in ubiquitin-dependent proteolysis of key cell cycle proteins by the 26S proteasome. The spatio-temporal degradation of mitotic cyclins and securins ensures the correct onset of the cell cycle phases and exit from the cell division program, respectively. The identification of genes encoding APC/C subunits …