CV Lattes
ORCID
Abstract
The APOE gene is identified as a major risk factor for late onset Alzheimer's disease and has three alleles, µ2, µ3 and µ4, related to two non-synonymous substitutions. The presence of the µ4 allele confers an increased risk for the disease in a dose dependent manner (odds ratio 12.9 for homozygous individuals and between 3.2 and 4.2 for heterozygous individuals). The most prevalent form …