Abstract
The GH pituitary secretion is regulated by negative feedback loops via hypothalamic neurons. In this regard, hypothalamic neurons that produce GHRH act by stimulating GH synthesis, whereas somatostatin (SST) acts as GH secretion inhibitor. However, only a small portion of the GHRH neurons express GH receptor (GHR) (Wasinski et al., J Neurosci 40: 4309-4322, 2020). In addition, our researc…