Abstract
Anaplastic thyroid carcinoma (ATC) is the most aggressive and fatal endocrine cancer. Due to the loss of thyroid cell differentiation, ATC does not uptake iodine, and thus, is refractory to radioiodine therapy. The molecular pathways altered in ATC pathogenesis are associated to mutations in MAPK, inactivation of TP53 and mutations in TERT promoter. However, additional alterations may con…