Introduction: Bachelor in Biological Sciences from Universidade Paulista (2018-2021) and master's student at UNESP IB/CLP, she is a member of two research groups: 1-Laboratory of Molecular Biology and Biochemistry of Peptides and Biologically Active Proteins (BIOMOLPep-CNPq) belonging to UNESP IB/CLP- Brazil, where she is supervised by Dr. Marcos Hikari Toyama; and Biomolecular SIMulations Research Group, belonging to the Faculty of Medicine of the University of Porto-Portugal, supervised by Dr. Sergio F. Sousa. Expertise: The master's student works in the areas of biochemistry, molecular biology, bioinformatics and ecotoxicology. She has experience in experimental biochemistry, working with High Performance Liquid Chromatography (HPLC), Circular Dichroism, pharmacological tests in vivo, in vitro and in silico. History: Isabelly Annunciato began her research activities through two scientific initiations awarded with scholarships, respectively: Scientific Initiation project approved (2018) and completed (2019) by Universidade Paulista in the areas of biochemistry and molecular biology, carried out with support and scholarship from Universidade Paulista (UNIP) and support from Universidade Estadual Paulista (UNESP); FAPESP Scientific Initiation scholarship. She has an English fluency certificate (Cambridge English Entry Level Certificate in ESOL International) (2019) and basic knowledge of Spanish.Annunciato, I. is currently doing part of his master's degree at the BioSim Laboratory at the University of Porto, Portugal, where she is developing Molecular Dynamics and Docking simulations. This partnership is funded by the São Paulo State Research Foundation (FAPESP) under the BEPE modality. (Source: Lattes Curriculum)
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Nitrosamines are compounds classified as emerging contaminants, carcinogens, and oxidants. They can alter the properties of cell membranes and inducing an increase in biologically active lipids, such as arachidonic acid and PAF, a potent pro-inflammatory agent capable of inducing the onset of liver diseases. In this work, we will use two nitrosamines (N-Nitrosodiethylamine and N-Nitrosodi…
Phospholipases A2 are a large family of enzymes that have the function of hydrolyzing the sn2 phosphodiester bond of phospholipids and releasing fatty acids, emphasizing unsaturated fatty acids of 18 to 20 carbons (PUFAs, w-3 and w-6) and acid arachidonic (C20: 4 w-6), whose subsequent metabolization by cyclooxygenase 2 (COX-2) generates bioactive pro-inflammatory and homeostatic lipids. …
Nitrosamines are compounds classified as emerging contaminants, carcinogens, and oxidants. They can alter cell membrane properties and induce an increase in biologically active lipids, such as arachidonic acid and PAF, a potent pro-inflammatory agent capable of inducing the onset of liver and inflammatory diseases. Lp-PLA2 (alternatively known as platelet-activating factor-acetylhydrolase…
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