Associate Professor of Pharmacology, UNESP, Botucatu, Sao Paulo, Department of Biophysics and Pharmacology. Pharmacist (2002), Master (2004), and Ph.D. (2007) in Pharmacology. Postdoctoral Research Fellow at the Department of Pharmacology (USP, 2009) and at Harvard Medical School (2016). Adviser of masters and Ph.D. students, Biomolecular and Pharmacological Sciences (UNESP, Botucatu, Sao Paulo). The main focus is cardiovascular pharmacology. (Source: Lattes Curriculum)
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It is likely that the Endothelial Dysfunction (ED) found in Hypertensive Disorders of Pregnancy (HDP) are evoked by the actions of multiple factors and several pathways. Then the discovery and the understanding of these converging pathways that contribute to ED and poor outcome of pregnancy can addressing potential molecules with are modulated by different drugs. The use of omics tools, s…
Preeclampsia (PE) is a disease that occurs in pregnancy and is characterized by elevated maternal blood pressure accompanied by endothelial dysfunction. Its pathogenesis is still not well understood; however, placental ischemia and hypoxia has shown importance in pathophysiology. In PE there is an increase in oxidative stress, increases in antiangiogenic factors and decreases in vasodilat…
Hypertensive disorders of pregnancy are characterized by an increase in systemic blood pressure. Preeclampsia is considered the most severe of these disorders and is usually accompanied by proteinuria and other clinical symptoms after the 20th gestational week. Perivascular adipose tissue (PVAT) may participate in the control of vascular tone through the release of vasoactive substances, …
Under gestation period, several cardiovascular adaptations must occur to maintain a healthy pregnancy. Preeclampsia (PE) is a disorder that occurs during pregnancy that is characterized by elevated maternal blood pressure (140x90mmHg) accompanied by proteinuria in 24-hour urine after the 20th week of pregnancy. Its pathogenesis is still unclear; however, the placenta seems to play a key r…
Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to isoflurane or sevoflurane. The alkaline single-cell gel electrophoresis …
(Only some records are available in English at this moment)
Nitric oxide (NO) is a critical endogenous mediator involved in various physiological aspects of healthy pregnancy, including implantation, placental perfusion, maternal systemic vasodilation, and renal adaptation during pregnancy. NO deficiency during pregnancy has been associated with various hypertensive disorders, such as preeclampsia (PE). S-nitrosylation represents the major route f…
In pre-eclampsia (PE), the hypoxia and ischemia generated by the inefficient development of spiral arteries due to failure of trophoblast invasion causes placental dysfunction and, consequently, generalized endothelial dysfunction. As a result, the dysfunctional placenta releases anti-angiogenic factors, pro-inflammatory antigens, and Reactive Oxygen Species (ROS). Moreover, oxidative str…
The gestational period is marked by several systemic adaptations, including cardiovascular, necessary for the development of a healthy pregnancy, meeting the fetal metabolic demand.Preeclampsia (PE) is a condition that occurs during pregnancy in which trophoblastic invasion and the formation of blood vessels at the maternal-fetal interface are impaired by factors that are still unclear. T…
(Only some records are available in English at this moment)
The gestational period is marked by several systemic adaptations, including cardiovascular, necessary for a healthy pregnancy, meeting the fetal metabolic demand. Pre-eclampsia (PE) is a complication of pregnancy with pathogenesis that is still unclear, but it is characterized by elevated maternal blood pressure. In a healthy pregnancy there is a normal trophoblastic invasion and formatio…
Although there were great advances in the diagnosis and treatment of hypertension during pregnancy, such conditions are still among the highest causes of maternal and perinatal morbidity and mortality worldwide. Nitric oxide (NO) derived from the endothelial nitric oxide synthase (eNOS) enzyme and matrix metalloproteinases (MMP-2 and MMP-9), play important roles in the vascular endotheliu…
Pre-eclampsia is a gestational hypertensive disorder characterized by systolic and diastolic blood pressure commonly greater than 140/90 mmHg and which usually appears after the 20th week of pregnancy. Studies suggest increases in oxidative stress and antiangiogenic factors in pre-eclampsia with a concomitant reduction in vasodilator mediators and deficient placentation, which are accompa…
(Only some records are available in English at this moment)
Preeclampsia affects 5-8% of pregnancies and is characterized by increased blood pressure and proteinuria from 20 weeks of gestation. These changes appear to be initially related to placental ischemia, causing insufficient uteroplacental oxygenation followed by increased release of anti-angiogenic factors such as sFlt-1 (soluble fms-like tyrosine kinase-1, which is a soluble VEGF receptor…
| 2 / 2 | Ongoing research grants |
| 6 / 5 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 22 / 20 | All research grants and scholarships |
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