Holds a bachelor's degree in Biomedicine from the University of Mogi das Cruzes (2000), a Master's degree in Biotechnology from the University of Mogi das Cruzes (2004) and a PhD in Biological Sciences (Molecular Biology) from the Federal University of São Paulo (2008). He is currently professor at level 1 of the University of Mogi das Cruzes and researcher at the University of Mogi das Cruzes. Our team studied the in vivo and in vitro effect of Metacaspases, which are proteolytic enzymes involved in programmed cell death (apoptosis) in unicellular organisms such as yeasts, protozoa and fungi. We performed cloning and site mutations aimed at chemical, physicochemical and structural characterization of these enzymes. We also evaluated the in vivo effect of Saccharomyces cerevisiae metacaspase, through immunofluorescence techniques, flow cytometry, among others using a model knocked out of this yeast for the metacaspase gene. (Source: Lattes Curriculum)
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The present research project is a continuation of the previous projects carried out by our research group, in which we produced yeast metacaspases in an expression system in E. coli, in their wild-type forms and containing site-directed mutations. Interestingly, yeast metacaspases are classified as belonging to group I, which has the characteristic of presenting its N-terminal region cons…
The present project is a continuation of the previous project, biochemical characterization of caspase-like cells involved in the simple eukaryotic cell cycle (FAPESP - 2015 / 11190-0), during the execution of the project we observed that the metacaspases of yeasts belonging to the group I of this class of enzymes, present in the N-terminal portion a sequence rich in glutamine and asparag…
The cell cycle is basically determined by the processes of cell division, differentiation and death. In recent a year's caspase family enzymes has been described which are involved in programmed cell death in a simple eukaryotic organisms such as fungi and protozoa (metacaspases) and in metazoan and amoeboid Dictyostelium sp (paracaspases), however, the biochemical characterization of the…
1.338 / 5.000Resultados de traduçãoResultado da traduçãoThe present research project aims to produce metacaspase from Saccharomyces cerevisiae (ScMCA-IA) containing site-directed mutations in the aspartate residues responsible for the interaction of calcium with this enzyme. The ScMCA-IA metacaspase undergoes self-processing to become catalytically active, and requires calcium ion as an e…
The present research project aims to obtain Plasmodium falciparum metacaspase 1 (PfMCA-Ia), protozoan metacaspases, which belong to group II of these enzymes, which have the characteristic of not presenting the non-polar portion in their N-terminus, being soluble and active in their monomeric form. In previous work by our group, we have already cloned, performed site-directed mutations an…
The present research project aims at the production of Saccharomyces cerevisiae (YCA1) metacaspase, including mutations in the site directed at the aspartate residues responsible for the interaction of alcohol with this enzyme. A YCA1 metacaspase undergoes automatic processing to become catalytically active, and uses calcium as an enzymatic co-factor both for its automatic processing and …
The cell cycle is determined primarily by the processes of division, differentiation and death, in organisms such as mammals it is described that cell death is linked to the action of enzymes known as caspases. In recent years enzymes of the caspase family have been described that are involved in programmed cell death in simple eukaryotic organisms such as fungi and protozoa (metacaspases…
Cell death is a biological process inherent in all living things. In eukaryotes superior to programmed cell death is mediated by enzymes called caspases, already in lower eukaryotes such as plants, fungi and protozoa, this process is controlled by enzymes called metacaspases. Studies indicate that these proteases have structural homology, however, differ in affinity cleavage with the subs…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 8 / 6 | Completed scholarships in Brazil |
| 13 / 11 | All research grants and scholarships |
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CV Lattes
ORCID