Abstract
The role epigenetic modifications on carcinogenesis process have received a lot of attention in the last years. Among those , the histones acetylation is a process regulated by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an important role in epigenetic regulation, allowing the control of the gene expression. HDAC inhibitors (HDACi) induce cancer cell cy…