Fernando de Castro Reinach

• FAPESP Genome Project: sequencing laboratory, AP.GEN
• The molecular mechanism of the ca+e-troponin switch: mapping the alternative sets of interdomain interactions present in the on and off states., AR.EXT

• Abstract

  The contraction of both skeletal and cardiac muscles is regulated by the intracellular free calcium concentration. A molecular switch capable of detecting fluctuations in calcium levels regulates the interactions between actin and myosin, the proteins responsible for force generation, and therefore muscle contraction. The existence of this switch, the general principles of its operation a…

  Regulation of Muscle Contraction: Site-Directed Mutants of Thin Filament Components, AP.TEM

(Only some records are available in English at this moment)