Abstract
The time required for the induction of neuroplastic responses in corticolimbic areas, such as the medial Prefrontal Cortex (mPFC), is thought to be one of the mechanisms that contribute to the late onset of action of Selective Serotonin Reuptake Inhibitors (SSRIs), which is one of the main limitations of these drugs in the clinical practice. In animal models based on the exposure to repea…