Abstract
Introduction: Down Syndrome (DS), caused by the chromosome 21 trisomy, is a more frequent genetic abnormality in the population, with one case in each 319 to 1,000 births. Its main phenotypic aspects are intellectual deficiency in varying degrees, short stature, generalized muscular hypotonia, craniofacial dysmorphia, and congenital heart diseases. Other comorbidities may be associated wi…