CV Lattes
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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Bachelor of Pharmacy, UFRGS, Porto Alegre, Brazil (2007) PhD, St. Vincent's Institute, University of Melbourne, Australia (2013) Postdoctoral Research Fellow, Genome Damage and Stability Centre, University of Sussex, UK (2014-2018) Assistant Professor, Department of Biochemistry, University of São Paulo (from 2018) Studies cellular mechanisms of DNA repair and DNA damage signalling mediated by a post-translational modification termed ADP-ribosylation. Has a special interest in human genetic disorders caused by mutations in these processes and, more recently, in the role of ADP-ribosylation in the context of the cellular response to viral infections. (Source: Lattes Curriculum)
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The search for anti-coronaviral treatments is largely focused on inhibitors of the viral polymerase or one of the viral proteases. However, the viral macrodomain contained in non-structural protein 3 (Nsp3) is an attractive and underexplored target, as it has a druggable catalytic pocket, is required for viral replication and is part of an important mechanism of active viral repression of…
Genomic instability is the main driving force for cancer onset and progression, underlies the ageing process and is associated with neurodegenerative disease. Protein post-translational modification by NAD+-derived ADP-ribose moieties plays central roles in orchestrating the cellular DNA damage response, but most of the human enzymes that catalyse this modification, as well as the hydrola…
Genomic instability is the main driving force for cancer onset and progression, underlies the ageing process and is associated with neurodegenerative disease. Protein post-translational modification by NAD+-derived ADP-ribose moieties plays central roles in orchestrating the cellular DNA damage response, but most of the human enzymes that catalyze this modification, as well as the hydrola…
DNA damage activates pleiotropic cellular responses such as cell cycle arrest and senescence, but can also induce an inflammatory interferon response, which is an anti-viral pathway activated by the presence of DNA in the cytoplasm. We have identified PARP9 and DTX3L, two proteins that form a heterodimer in cells and are expressed from a shared interferon-responsive promoter, in a screen …
The virus that causes severe acute respiratory syndrome 2 (SARS-CoV-2) has triggered one of the biggest pandemics seen by humanity, leading to millions of deaths worldwide. Although the development of vaccines has taken place in record time and has provided a substantial reduction in the number of deaths from COVID-19, the development of drugs with antiviral activity remains a necessity, …
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DNA damage activates pleiotropic cellular responses such as cell cycle arrest and senescence, but can also induce an inflammatory interferon response, which is an anti-viral pathway activated by the presence of DNA in the cytoplasm. We have identified PARP9 and DTX3L, two proteins that form a heterodimer in cells and are expressed from a shared interferon-responsive promoter, in a screen …
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| 6 / 6 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 10 / 10 | All research grants and scholarships |
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