Abstract
Tumors of the central nervous system (CNS) are a frequent cause of death in children and adolescents. Recently, changes in epigenetic mechanisms have been implicated in the oncogenesis of high-grade gliomas (HGG) in children. Mutations in histone H3F3A (K27M or G34R/V/W) were related to tumor location and prognosis of pediatric gliomas. Clinically, several preclinical and clinical studies…