Bachelor of Biological Science by the Federal University of Lavras. Master's student in Immunology by Immunology post-graduate program in Biomedical Sciences Institute IV - São Paulo University. Developing research about Immunopharmacology and Immunemetabolism analyzing the role of leukotrienes in macrophages metabolic reprogramming in type 1 diabetes. (Source: Lattes Curriculum)
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Brown adipocytes are known for their thermogenic potential, initiated by the activation of adrenergic receptors coupled to a G protein. The activation of these receptors in cells with high metabolic activity leads to an increase of intracellular cyclic AMP (cAMP), which, in excess, is pulled out of the cell by MRPs (Multidrug Resistance Proteins) channels. Extracellular cAMP/AMP can be co…
Type 1 diabetes (T1D) is a metabolic disease related to persistence of low gradesystemic inflammation. Fat mass loss is one of the characteristics of T1D in patients andmice. Our group has shown that T1D mice have high systemic levels of leukotriene B4(LTB4) and this lipid mediator is involved in metabolic alterations as well in systemic andcellular inflammation in T1D animals. We reporte…
Despite aggressive glucose monitoring and insulin therapy, many patients spend large portions of the day in a hyperglycemic state, placing them at risk for the development of comorbidities. Chronic hypoinsulinemia in diabetes drives systemic inflammation that contributes to many comorbidities, including weight loss, dyslipidemia, low grade inflammation and enhanced risk of infection. Our …
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CV Lattes
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