graduation at Farmácia from Universidade de Ribeirão Preto (2019). (Source: Lattes Curriculum)
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Head and neck squamous cell carcinoma (HNSCC) has high incidence and recurrence rates. In addition to genomic alterations, epigenetics, such as dysregulation of microRNAs (miRNAs), also occur in HNSCC. Recently, our research group characterized the relationship of sphingolipids and sphingosine kinase 2 (SK2) with oral squamous cancer. Furthermore, the RNA sequence data showed the deregula…
Oral carcinoma is responsible for many deaths around the world and it has high capacity to develop recurrences and metastases due to failures in therapy promoted by chemoresistance. Conventional treatments such as radio and chemotherapy are capable of destroying differentiated cells of the tumor, but a small population called cancer stem cells remains intact and repopulates the tumor. Man…
Head and neck squamous carcinoma are solid tumors with heterogeneous properties. Inside a tumor only a few cells have the capability to self-renewal and unlimited growth. In the tumor, is well established that cancer stem cells are responsible for tumor growth and differentiated cells only contribute to the tumor bulk. There are two hypotheses to explain the origin of the cancer stem cell…
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