BS in Animal Science - University of São Paulo, including research training under supervision of Dr. Lawrence C. Smith - University of Montreal, Canada. PhD in Medical Physiopathology - State University of Campinas, under supervision of Dr. Aníbal E. Vercesi and Dr. Flávio V. Meirelles; research training under supervision of Dr. Joanna Poulton - University of Oxford, UK. Post-doctoral researcher at University of São Paulo. Currently is Associate Professor - Department of Genetics and Evolution, Federal University of São Carlos. He is interested in the study of female fertility and mitochondrial genetics in mice, cattle and humans. Towards that, his group undertake experiments based on the use of genetic modified animals as well as cultured primordial germ cells (PGCs), oocytes, embryos and stem cells. (Source: Lattes Curriculum)
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Bovine in vitro embryo production (IVP) is one of the most used reproductive biotechnologies, being Brazil raked in the runner-up position among countries making use of this technology. Embryo cryopreservation is required for storing exceeding embryos and transport to other regions/countries, but the efficiency of this technology is considered low, with a range of outcomes following cryop…
Growing evidence supports that maternal obesity predispose the offspring to cardiometabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies involving humans and mice have found that metabolic disease represses mitofusin 2 (MFN2) expression, further impacting mitochondr…
This proposal is based on previous findings of M. Chiaratti's group, which with the expertise provided by the H. Clarke's group seeks to characterize mitochondrial dynamics in oocytes in greater depth, with potential implications to human welfare and health. The proposed scientific activities will investigate three hypotheses in mice: 1) Mfn1 conditional knockout (cKO) inhibits the P13K1A…
This proposal refers to the visit of Dr. Anand Kumas Pandey to our research group at Laboratory of Genetics and Biotechnology, Department of Genetics and Evolution, Federal University of São Carlos, during a period of 12 months. Dr. Pandey owns a large experience with the study of folliculogenesis and the pharmacologic control of it in mammals. The main goal of his visit is to strength ou…
Mitochondria play a fundamental role during oocyte growth. As a result, the existence of dysfunctional mitochondria or mutant mitochondrial DNA (mtDNA) in oocytes may lead to infertility syndromes and transmission of mitochondrial diseases. Compared to other cell types, oocyte mitochondria distinguish by their increased number, smaller size and rounded shape. These characteristics are dep…
(Only some records are available in English at this moment)
Cardiopathies are a major determinant of deaths worldwide and several studies support that maternal obesity predisposes the offspring to cardiovascular diseases. Among the factors contributing to this maternal effect, growing evidence indicates a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. For instance, obese mice harbor oocytes with mitochondria…
Growing evidence suggests that maternal obesity predisposes offspring to cardiometabolic disorders. In this context, previous studies point to a possible role of mitochondrial and endoplasmic reticulum (ER) dysfunction in the oocyte. In parallel, human and mouse studies report that metabolic diseases mitigate mitofusin2 (MFN2) expression, impacting mitochondria-ER contact sites (MERCs) in…
Growing evidence supports that maternal obesity predisposes the offspring to metabolic syndromes. In this respect, previous reports have indicated a possible role for mitochondrial and endoplasmic reticulum (ER) dysfunction in oocytes. In parallel, studies involving humans and mice have found that metabolic disease represses mitofusin 2 (MFN2) expression, further impacting mitochondria-ER…
Mitochondrial dynamics regulates several characteristics of mitochondria such as architecture, activity, transport, interaction with other organelles, inheritance and degradation. Important defects in mitochondrial dynamics typical of aging, for example in the autophagic pathway, result in the accumulation of damaged mitochondria and development of pathologies in mice and humans. This is …
Mitochondria are organelles essential to oocyte development, characterized by their round shape, small size and increased amount. These characteristics rely on mitochondrial dynamics, which determine organelle activity, transport and degradation. Mitochondrial dynamics is determined by fusion and fission events. Moreover, fusion of the outer mitochondrial membrane is mediated by mitofusin…
Mitofusins 1 (Mfn1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and being involved in the regulation of mitochondrial fusion. Since Mfn2 is also present in the membrane of the endoplasmic reticulum (ER), it is also responsible for regulating the morphology and the interaction of ER with the mitochondrion. Thus, there are increasing evidences that Mfn…
(Only some records are available in English at this moment)
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Transmission of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in t…
The determining role of mitochondria in regulating follicular development and oocyte growth is emerging from basic research on model species and clinical studies on female infertility. This new branch of research has been dedicated to deciphering the relationship between oocyte developmental competence and bioenergetics. Mitochondrial activity depends, among other things, on its organelle…
Diseases caused by mutations in mitochondrial DNA (mtDNA) affect ~1 in 4,300 people. In addition, almost every person carries very low levels of mutated mtDNA, which may be transmitted down to the maternal lineage and associate with late-onset degenerative diseases. Inheritance of mutated mtDNAs in germ cells relies upon the mitochondrial bottleneck, which results in drastic changes in th…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 14 / 11 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 32 / 27 | All research grants and scholarships |
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CV Lattes
ORCID