Abstract
Tumor suppressor genes are essential for the recognition and repair of genetic damages. They prevent the occurence of mutations that may lead to a clone of malignant cells. When cell cycle can not be stopped, p53 induces apoptosis. However, polymorphisms at codon 72 and codon 47 of the gene impair p53 apoptotic ability. 72p53 polymorphism is associated with a series of human tumors but it…