Undergrad student of Pharmacy-biochemistry at University of São Paulo (2014-), having projects in the area of Organic Synthesis and Drug Design, with exchange period at Rijksuniversiteit Groningen(2016-2017), where he worked with Multi-component Reactions(MCR) with emphasis on isocyanide compounds. Currently working in the Drug Design area, with projects on dendrimeric pro-drugs financed by FAPESP(São Paulo Research Foundation). (Source: Lattes Curriculum)
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Chemical fragment-based Hit Discovery (FBHD) is an effective tool for the discovery of lead molecules and was responsible for the development of several FDA-approved drugs. In our group, we study RNA binding proteins containing the KH domain, which allows a protein to bind to a specific set of mRNAs in the cell and to control processes as transport of RNAs from the nucleus and RNA splicin…
Fragment-based Hit Discovery (FBHD) is a new and effective tool for the discovery of lead molecules both in industry and academia and is responsible for the development of several FDA-approved drugs. Its strategy of screening libraries of very small molecules allows for covering a vast chemical space with fewer compounds, which permits an accelerated and cheaper method for drug design whe…
Tuberculosis is part of a group named Neglected Diseases 2.0, which includes "The Big Three" diseases: Malaria, AIDS and Tuberculosis. Combined, they killed around six millions of people worldwide in the last year, according to World Health Organization. For this reason, they have been included in programs such as blue marble health, to encourage research, public policies and investment, …
Tuberculosis registered, in 2017, 10 million new cases, resulting in 1.4 million of deaths, putting the disease in the top ten death causes in worldwide, and the most fatal infectious disease in the world. In Brazil, there were 72,000 new cases in 2016, with 4,500 deaths, classifying the country as high tuberculosis burden. Dendrimers, on the other hand, have shown a lot of biological app…
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