Douglas dos Santos in research grants and scholarships supported by FAPESP.
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Clearance of dying cells is a pivotal function of the immune system. During the phagocytosis of apoptotic cells (efferocytosis), some components of the autophagy machinery can be directly recruited to the phagosome membrane, leading LC3 lipidation and mediating phagolysosomal maturation. This process is known as LC3-Associated Phagocytosis (LAP). We have recently established that LAP regu…
Clearance of dying cells is a pivotal function of the immune system. During the process of phagocytosis of apoptotic cells some components of the autophagy machinery can be recruited, leading to the lipidation of LC3 in the phagosome membrane, which facilitates its maturation and fusion with the lysosome. This process is known as LC3-associated phagocytosis (LAP). We have recently establi…
Tuberculosis (TB) is a chronic infectious disease, whose focus is primarily pulmonar, and is transmitted by the bacillus Mycobacterium tuberculosis. Type II alveolar epithelial cells (AEC-II) are among the first cells to come into contact with M. tuberculosis. The bacilli growth in AEC-II is faster than in alveolar macrophages, what makes epithelial cells propitious reservoirs to the deve…
Clearance of dying cells is a pivotal function of the immune system. During the phagocytosis of apoptotic cells (efferocytosis), some components of the autophagy machinery can be directly recruited to the phagosome membrane. This recruitment catalyzes the lipidation of proteins from the LC3-GABARAP family onto phosphatidylethanolamine and phosphatidylserine residues on the phagosome membr…
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | All Scholarships |
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