Abstract
From the analysis performed by SAGE (Serial Analysis of Gene Expression) on benign and malignant thyroid samples, with subsequent validation by real-time PCR and immunohistochemistry, we found that the combined expression of five markers (PVALB, ITM1 and C1orf24, ARG2 and DDIT3), can distinguish benign and malignant thyroid lesions with high sensitivity and specificity. Among these, PVALB…