Abstract
The present study aims to evaluate the pro-osteogenic effects of the phytocystatins CsinCPI-2 and CaneCPI-5, through in vitro and in vivo studies. Specifically, the in vitro study will assess the modulating impact of phytocystatins on the response of mouse bone marrow-derived macrophages (BMDMs) and on the osteoblastic differentiation of primary undifferentiated mouse bone marrow mesenchy…