Phd student in biochemical and pharmaceutical technology, FCF/USP. Bachelor of Science in Biomedical Sciences, ICB/USP (2018). (Source: Lattes Curriculum)
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Melanoma is a malignant skin neoplasm with high plasticity, chemoresistance, and propensity to metastasis. A significant percentage of patients with this disease have BRAFV600E mutation and can be treated with Vemurafenib. Although this drug has an effective initial response, a significant number of patients have tumor resistance and disease progression after a short period of treatment i…
A significant number of patients with acute leukemia of lymphocytic (ALL), malignant cells have a metabolic defect in the synthesis of asparagine (Asn), depending on an exogenous source of this amino acid to survive. The enzyme L-asparaginase is used in the treatment of this disease in order to exhaust the stocks of asparagine in the bloodstream required for tumor cells. Although this enz…
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