Abstract
Evaluation of Targeted Rescue Therapy of Polycystin-1 Missense Mutations in ADPKD by Upregulation or Activation of the Transcription Factor XBP1Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal monogenic disorder. It is caused by mutations in one of two genes, PKD1 and PKD2, coding respectively the polycystin-1 (PC1) and polycystin-2 (PC2). The fo…