graduation at Odontologia from Universidade Estadual de Campinas (2000), master's at Odontology from Universidade Estadual de Campinas (2003) and doctorate at Odontology from Universidade Estadual de Campinas (2006). Has experience in Odontology, acting on the following subjects: s. mutans, biofilm, microbiologia, porphyromonas gingivalis and bacteroides forsythus. (Source: Lattes Curriculum)
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Microbial biofilms are ubiquitous and fundamental for several natural and industrial processes and disease development. Dental caries results from dysbiosis in biofilm caused by microbial metabolism of dietary carbohydrates. These carbohydrates are substrates to produce extracellular matrix components and organic acids. These acids are trapped by the matrix inside the biofilm and at the i…
Dental caries is a worldwide public health problem caused by the interaction between microorganisms in the biofilm and the diet. A diet rich in carbohydrates provides substrates for acid production and extracellular matrix build-up. This matrix is comprised mostly of exopolysaccharides and maintains the acids inside the biofilms and at the interface biofilm-teeth surfaces, hindering the n…
Microorganisms living as biofilms cause several human diseases. Biofilm control and treatment have challenges that need to be overcome. Therefore, understanding these microbial communities and the extracellular matrix that ensures the maintenance of biofilm is paramount for the development of preventive and therapeutic strategies. Recent advances in nanoengineering and nanotechnology can …
Dental caries is a costly biofilm-dependent disease that affects children and adults alike worldwide. The assembly of biofilms depends on the formation of an extracellular matrix (ECM). Exopolysaccharides are key components in the ECM while both extracellular DNA (eDNA) and lipoteichoic acids (LTA) are found in high amounts in cariogenic biofilms. Streptococcus mutans orchestrates the bio…
It is unknown how the amino sugars N-Acetylglucosamine (GlcNAc) and glucosamine (GlcN) influence the extracellular matrix build-up in dental biofilm. It is unknown whether the presence of GlcNAc and GlcN in a sucrose-rich diet (with starch) can minimize the diet's cariogenicity. Sucrose is the main substrate for exoenzymes glucosyltransferases to synthesize exopolysaccharides (glucans), a…
It is unknown how changes in cellular hydrophobicity, the fatty acid composition of the cell membrane, and cell wall and cell membrane structure, triggered by agents used for controlling S. mutans biofilm formation, contribute to the alteration of biofilm formation. The cell wall provides sites for extracellular matrix components bridging the cells within the biofilm, while cell wall and …
Dental caries is a worldwide public health problem caused by the interaction between microorganisms in the biofilm and the diet. A diet rich in carbohydrates provides substrates for acid production and extracellular matrix build-up. This matrix is rich in exopolysaccharides to which extracellular DNA and lipoteichoic acids are associated. The matrix maintains the acids inside the biofilms…
Dental caries occurrence depends on the host diet that causes ecological and structural shifts in the dental biofilm. This biofilm is formed by several microorganisms that are organized as microbial cells communities enmeshed in self-produced extracellular polymeric substances, the extracellular matrix. Among these microorganisms, Streptococcus mutans is associated with dental caries deve…
Dental Caries is a multifactorial disease that leads to the destruction of dental tissue. The difficulty of eradicating this condition demands new approaches to its control. Therefore, the objective is to prepare formulations with crude extracts and fractions (combined or not with fluoride) of Casearia sylvestris (Biomes Atlantic Forest, Cerrado, Ecotone-Cerrado/Caatinga and varieties syl…
(Only some records are available in English at this moment)
The development of effective therapies for oral biofilm control is challenging. Topical agents used to treat and prevent oral diseases are not kept in the mouth for sufficient time; consequently, they cannot exert their maximum therapeutic potential. Therefore, nanoparticles carrier (NPC) for drug delivery were developed that bind to the surface of hydroxyapatite (the main mineral of teet…
| 1 / 1 | Ongoing research grants |
| 6 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 13 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 24 / 18 | All research grants and scholarships |
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CV Lattes
ORCID