graduate at Engenharia Industrial Química from Faculdade de Engenharia Química de Lorena (2001) and master's at Engenharia Química from Universidade de São Paulo - Escola de Engenharia de Lorena (2006). Has experience in Chemical Engineering, focusing on Chemical Engineering, acting on the following subjects: lcst, rmn 1h, n-vinilcaprolactama, poli(n-vinilcaprolactama) and polymer caracterization. (Source: Lattes Curriculum)
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Since most photosensitizing and chemotherapeutic agents are poorly soluble in water, leading to their rapid elimination from the bloodstream, encapsulation or association of such agents with suitable materials can improve their in vivo solubility and stability. Thus, this project aims to explore polymer nanoparticles, capable of combining photodynamic therapy (PDT) with chemotherapy in a …
The combination of photodynamic therapy (PDT) and chemotherapy is one attractive regime for cancer medication. Nanoparticulate delivery of PDT/chemotherapy payloads involves the highly complex biological, chemical, and transport barriers, among which the rapid cargo release into cytoplasm is one critical step. The generation of traditional triggered-release nanocarriers often necessitates…
The developing of new carrier systems for active ingredients aim to modify the limiting physicochemical properties of drugs, improving thereby its pharmacodynamic (therapeutic effect potentiation), pharmacokinetics (control of the absorption and distribution on tissues) and reducing their toxic effects (local and systemic toxicity). The modification of the permeability and solubility of a…
Cancer represents one of the greatest threats to human health and Hepatocellular Carcinoma (HCC) is one of the most incident Cancers and the third main reason of Cancer death worldwide. Thus, the development of new and more effective therapies against HCC has attracted increased attention in the medical and pharmaceutical fields, since traditional chemotherapy treatments do not have a hig…
Taking into account the great interest in the preparation of biocompatible, biodegradable and stimuli-responsive polymeric materials for use in drug controlled release, this research project aims the synthesis of poly(µ-caprolactone)-b-poly(N-vinyl caprolactam) (PCL-b-PNVCL) block copolymers; where a block is biodegradable (PCL) and the other is biocompatible and thermosensitive (PNVCL). …
(Only some records are available in English at this moment)
In the project developed at EEL-USP, the student evaluates the use of a cationic copolymer, obtained from the chemical modification of the polysaccharide pullulan (PUL). The final material has the ability to self-aggregate in aqueous media forming biodegradable nanoparticles, to study the encapsulation and release, in a controlled manner, localized and with synergistic effect, of two chem…
The Scientific Initiation research project carried out by Graziele Aparecida de Jesus Aguiar, undergraduate student in the Polymer Laboratory of the EEL/USP, under the supervision of Prof. Dr. Simone de Fatima Medeiros and Prof. Dr. Amilton Martins dos Santos, aims the use of biocompatible and thermoresponsive block copolymers in developing systems for controlled drug delivery. The first …
| 4 / 3 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 18 / 15 | All research grants and scholarships |
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CV Lattes
ORCID