CV Lattes
Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduate in Biological Sciences from Universidade Paulista (2009 Campus Araçatuba) and Master in Physiological Sciences from Universidade Estadual Paulista "Júlio de Mesquita Filho" (2012, Campus Araçatuba).Currently she is a doctoral student at the Multicenter Post-Graduate Program in Physiological Sciences. Has experience in cardiovascular physiology and pharmacology. (Source: Lattes Curriculum)
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The endothelial glycocalyx is formed primarily of proteoglycans, glycoproteins and glycosaminoglycans (GAGs) and has been described as a structure responsible for mechanotransduction which is a translation of the biomechanical forces in biochemical signaling in endothelial cells, promoting activation of endothelial nitric oxide synthase (eNOS) and production nitric oxide (NO). Essential h…
The glycocalyx is a known regulator of eNOS activity and thus, a regulator o NO production. We have made the novel discovery that knockout animals for glypican-1 and syndecan-1, components of the glycocalyx, have impaired endothelium-dependent vasodilation and vasocontriction. These effects are more significant in the glypican-1 knockout (Gpc-1-/-) when compared to the syndecan-1 knockout…
The glycocalyx interacts directly with hemodynamic forces from blood flow and, consequently, is a prime candidate for mechanosensing. We hypothesize that the mechanotransduction pathways activated by increased intravascular pressure in glypican-1 and syndecan-1 knockout mice are impaired when compared to wild-type mice, decreasing nitric oxide synthase activation and nitric oxide producti…
| 1 / 1 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 3 / 3 | All Scholarships |
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