bachelor's at Farmácia e Bioquímica from Universidade de São Paulo (2005) and doctorate at Physiology from Universidade de São Paulo (2010). , acting on the following subjects: desnutrição, desnutrição protéica, progenitores hematopoéticos, ciclo celular and hemopoese. (Source: Lattes Curriculum)
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How the microbiota communicates with the host and contributes to health is a key question for progress in this research field. Bacterial metabolites called short chain fatty acids (SCFAs), which are generated by fermentation of non-digestible carbohydrates, constitute a link between microbiota and host cells. Previous studies demonstrated that these metabolites regulate host metabolism an…
The Covid-19 pandemic has impacted public health dramatically in several countries. In this context, understanding the factors related to the serious forms of Covid-19 is essential for prevention and, possibly, treatment of patients. Recent studies show that the intestinal microbiota and its products play a fundamental role in respiratory infections by other viruses including respiratory …
Short chain fatty acids (SCFAs) are products derived from the intestinal microbiota, which are produced mainly by the fermentation of dietary fibers. Found in high concentrations in the colon, SCFAs exert important functions for the maintainance of intestinal homeostasis including providing energy for intestinal epithelial cells (IECs), regulating their proliferation and apoptosis and mod…
In the present project, we wish to lest the hypothesis that SCFA regulate innate immunity of intestinal epithelial cells (enterocytes and related cells) by affecting histone modifications, especially modifications that may metabolically directly relate to SCFA, such as lysine acetylation and crotonylation. To test our ideas we will employ intestinal organoid culture ("mini-guts"), mouse m…
(Only some records are available in English at this moment)
The intestinal commensal microbiota, in a symbiotic relationship with the host, provides the necessary stimuli to promote the production of antimicrobial peptides, increased barrier function, and proliferation of Intestinal Epithelial Cells (IECs). This interaction, which can occur through the recognition of Pathogen-Associated Molecular Patterns (PAMPs) by Toll-Like Receptors (TLRs), is …
The regulation of the proliferation and differentiation of intestinal stem cells (SSIs) is crucial for intestinal homeostasis. These processes are, in part, regulated by microbiota signals, especially short-chain fatty acids (AGCCs), which induce Post-Translational Modifications (PTMs) including histone acetylation and crotonylation, which are important in the regulation of gene expressio…
The intestinal microbiota plays a fundamental role in the modulation of hematopoiesis and consequently in the production of neutrophils. This modulation can occur due to microbial components or metabolites derived from the microbiota. Short-chain fatty acids (SCFAs), produced by the intestinal microbiota through the metabolism of non-digestible carbohydrates from the diet, are molecules t…
Interactions between microbiota and the host immune system are essential for homeostasis maintenance. Previous work by the group showed that the deletion of a chromatin remodeling factor called Smarcad-1 in intestinal epithelial cells resulted in a change in this interaction, establishment of different composition microbiota, and resistance to induction of colitis by DSS relative to contr…
Short-Chain Fatty Acids (SCFAs) from the fermentation of fiber-rich diets by the intestinal microbiota play important modulatory functions in the intestinal epithelium. These metabolites regulate genes involved in the energy metabolism of Intestinal Epithelial Cells (IECs) by stimulating oxygen consumption and, consequently, the activation of Hypoxia-Inducible Factor (HIF). Several studie…
(Only some records are available in English at this moment)
Fermentation of inulin fiber is known to induce IL-22 production, enhancing barrier function and epithelial regeneration. Gamma-delta T cells in the gut produce IL-22 and interact directly with IECs through the Myd88 axis. Furthermore, gamma-delta cells can sense nutrients from the diet, reprogramming their activity depending on the diet composition. Although the inulin diet has shown eff…
The intestinal microbiota plays a key role in promoting hematopoiesis and generating immune cells. This modulation occurs directly by host-commensal species interaction or indirectly though metabolites derived from the microbial metabolism. Short-chain fatty acids (SCFAs) are some of these molecules that are produced from dietary fibers by gut bacteria. They mainly activate protein-couple…
Neutrophils constitute the most abundant population of circulating leukocyte cells and are the first cells to migrate and accumulate in tissues during inflammation and microbial infections. In addition to their ability to phagocyte and eliminate infectious agents through their antimicrobial mechanisms, they also constitute a relevant source of cytokines and eicosanoids that regulate the a…
(Only some records are available in English at this moment)
Increased severity of SARS-CoV-2 infection has been observed in obese patients. However, there is scarce information about the mechanisms involved in the association between obesity and COVID-19 pathogenesis. The gut microbiota has recently emerged as an essential component during respiratory viral infections. The purpose of this project is to investigate the impact of obesity on gut micr…
Dietary fibers are fermented by the intestinal microbiota generating important metabolites known as short-chain fatty acids (SCFAs). These molecules act differently on various cell lineages through three main pathways: activation of G protein-coupled receptors (GPCRs), HIF-1± stabilization and inhibition of histone deacetylases (HDACs). Recently, it has been shown that specifically on int…
The innate lymphoid cells (ILC) are a heterogeneous population of cells that, despite its morphological and effector similarities with T-lymphocytes, do not express T cell receptors and act in the first line of defense. These cells are found along the intestinal mucosa and play a fundamental role in the direct and indirect interactions between the microbiota and host cells. Bacterial meta…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 18 | Completed scholarships in Brazil |
| 5 / 5 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 35 / 35 | All research grants and scholarships |
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