Holds a bachelor's degree in biological sciences - emphasis on biotechnology from the Universidade do Vale do Itajaí (2005). Received his PhD from the Department of Physiology and Biophysics, Institute of Biomedical Sciences of the University of São Paulo, where he was a FAPESP postdoctoral fellow investigating the effects of omega-3 fatty acids on energy metabolism (2011). Worked at the Technical University of Munich (TUM) investigating postprandial metabolic adaptations, using mass spectrometry to identify markers of phenotypic flexibility. At the French National Institute for Agricultural Research (INRA) he developed research in search of new metabolites of dietary monoterpenoids using in silico tools to predict the metabolism of xenobiotics and high resolution mass spectrometry. He is a professor in the Department of Food and Experimental Nutrition of the Faculty of Pharmaceutical Sciences of the University of São Paulo acting in the area of metabolomics in food and nutrition. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Bile acids (BA) are amphipathic compounds produced by the liver that participate in the emulsification of dietary lipids. Due to the nature of the enterohepatic circulation and the partial escape of these molecules from first-pass absorption by the liver, plasma concentration of BA increases up to 20-fold after the ingestion of a meal, similarly to what occurs with certain hormones. In th…
We propose the execution of a clinical study conducted remotely, with minimally invasive, low-cost blood sampling techniques, whose execution is compatible with the limitations imposed by the COVID-19 pandemic. This study will serve as proof of feasibility of a remote clinical trial and will have as its central objective the investigation of the effects of D-limonene on postprandial inter…
The health effects of flavonoids and other bioactive compounds found in oranges have been studied for a long time. On the other hand, bioactive phytochemicals found in citrus such as d-limonene, have not yet been properly studied. Due to its antimicrobial activity, we believe that d-limonene can modulate the composition of intestinal microbiota, responsible for metabolizing bile acids. Bi…
Endocannabinoids are lipids derived from polyunsaturated fatty acids fromlong chains that combined with their synthesis and degradation enzymes and receptorsCB1 and CB2, comprise the endocannabinoid system, responsible for triggering severalphysiological effects. This study aims to clarify the relationship between menopause and changes inplasma concentration of endogenous cannabinoids dur…
This project seeks to characterize an animal model to study postprandial metabolic changes and investigate possible associations between the increase in plasmatic concentration of bile acids after ingestion of a meal with the other metabolic and inflammatory changes observed in this period.The main functions of the undergraduate student will be:a) Assist in the maintenance of animals in t…
The increase in life expectancy is a worldwide phenomenon, that brings together increased incidence of non-communicable chronic diseases, normally observed in aging individuals. The desired lifespan extension is also accompanied by longer periods of life where chronic diseases are also observed. Menopause is a natural process entangled with aging in women, that normally takes place in the…
(Only some records are available in English at this moment)
D-limonene, found mainly in orange peel, is associated with several beneficial properties, including hypolipidemic, hypoglycemic and antimicrobial effects. Bile acids are cholesterol-derived molecules that are involved in the emulsification of dietary lipids, in addition to having endocrine effects, with the potential to modulate the metabolism of lipids and carbohydrates. Their metabolis…
Brazil is one of the largest producers and exporters of oranges and orange juice in the world. Among the by-products of this citrus chain, the essential oil of orange peel has great economic value. This oil contains high amounts of the monoterpene D-limonene, to which lipid-lowering effects are attributed, among several actions in different physiological processes. Despite the effects dem…
The incidence of chronic diseases associated with dyslipidemia and insulin resistance is a serious public health problem. In animal models, it has been shown that D-limonene, a monoterpene abundant in citrus fruits contributes to reduce the circulating concentrations of lipids and glucose. The mechanism by which monoterpenoids modulates intermediate metabolism has not yet been fully eluci…
(Only some records are available in English at this moment)
Omega-3 polyunsaturated fatty acids (n-3 PUFA) are associated with the prevention of insulin resistance. These molecules increase peroxisomal ²-oxidation of fatty acids (FA) and stimulate peroxisome proliferation in the liver through the activation of peroxisome proliferator activated receptors (PPAR). This project is based on the hypothesis that other than increasing peroxisomal FA ²-oxi…
| 1 / 1 | Ongoing research grants |
| 3 / 3 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 7 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 17 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID