Abstract
The proteinase domain of hemorrhagic snake venom metalloproteinases (SVMPs) is believed to function to degrade capillary basement membranes, endothelial cell surfaces, and stromal matrix ultimately causing extravasation of capillary contents into the surrounding stroma. Hemorrhagic factor 3 (HF3) is a glycosylated P-III SVMP isolated from Bothrops jararaca venom. HF3 is an extremely activ…