Abstract
Staphylococcus aureus is a bacterium responsible for a wide range of diseases, with the Staphylococcal Scalded Skin Syndrome (SSSS) being one of the most serious. The skin damage in SSSS is caused by S. aureus Exfoliative Toxins (ETs), which are Chymotrypsin-Like Serine Proteases (CLSPs) that cleave the cadherin desmoglein-1 (Dsg-1). Four ETs of the CLSP family have been identified so far…