Abstract
Non-alcoholic liver disease associated with metabolic dysfunction (MAFLD) is a heterogenous group of diseases that comprise from a simple liver steatosis (NAFL) to more severe conditions such as Steatohepatitis (NASH), Cirrhosis and Hepatocellular Carcinoma (HCC). The PI3K-mTORC2-Akt-mTORC1 signaling pathway is directly involved in the NAFL-NASH-HCC progression and overactivated in 40-50%…