graduation at Ciências Biomédicas from Universidade de São Paulo (2017) and doctorate at Programa de Pós-Graduação em Medicina Tropical e Saúde Internacional from Instituto de Medicina Tropical (2023). Has experience in Immunology, acting on the following subjects: plasmodium falciparum, microrna, biotecnologia, l-arginina and var genes. (Source: Lattes Curriculum)
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Protozoan parasites of the Leishmania genus cause leishmaniasis by establishing their replicative niche in the interior of macrophage's phagolysosomes. In this interaction, diverse responses that limit parasite growth are triggered, such as activating the multimeric protein complex inflammasome. The Nod-like receptor Pyrin domain 3 (NLRP3) inflammasome is involved in processing pro-IL-1² …
Leishmania is an obligate intracellular parasite in the mammalian host, infecting phagocytic cells of the immune system. Inside the macrophage, the amastigote form is capable of subverting the hostile environment of the phagolysosome modulating host gene expression for its survival. L-arginine is a common substrate for both Nitric Oxide (NO) or polyamines production by macrophage enzymes …
The establishment of Leishmania infection in macrophages depends on the subversion of the immune response of this host cell to the parasite. One of these subversion mechanisms consists in the modulation of the L-arginine metabolism, a common substrate of nitric oxide (NO) and polyamines production pathways. This regulation directly influences the survival of the amastigote in the phagolys…
Metabolomic is emerging as an important tool to characterize macrophage phenotype, that, combined to genetic approaches, allows deciphering gene expression regulation in its ultimate phenotype, the metabolism. Metabolic rewiring during Leishmania infection was extensively studied in murine macrophages, but the differences to human immunology are increasingly being studied. Leishmania poss…
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CV Lattes
ORCID