Abstract
Immune modulation therapy with omega-3 polyunsaturated fatty acids (É-3) and low-dose aspirin (ASA) as adjunct to periodontal debridement (PD) has shown superior results than PD alone for the treatment of periodontitis in two randomized clinical trials (RCTs) with follow-up of 6 months. However, to date no placebo-controlled RCT has evaluated the effects of this therapy associated with sy…