Graduated in Dentistry at Piracicaba Dental School/University of Campinas (FOP/UNICAMP) (2003); MSc (2006) and PhD (2009) in Pharmacology, Anesthesiology and Therapeutics at the same institution. Performed postdoctoral in Biology Institute/University of Campinas (2011) and in Piracicaba Dental School (2012-2014). Was Assistant Professor at the Department of Biosciences at FOP/UNICAMP from 2014-2023 and became Associate Professor in 2023. Has research interest in the development of formulations and drug delivery systems, including liposomes and nanocapsules for local anesthetics, aiming to improve the quality of local and topical anesthesia in dentistry. Has experience in several in vitro and in vivo models and clinical trials. (Source: Lattes Curriculum)
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Local anesthesia (LA) is necessary to perform most dental procedures. However, although essential, LA is much feared by patients with needle phobia, which can harm the oral health of those who avoid dental treatment for this reason. Thus, topical anesthesia is performed long before LA to reduce the discomfort of the injection. In addition, it can also be used to perform small procedures o…
This current proposal aims to evaluate the feasibility of microneedles (MNs) as a drug delivery device at the oral mucosa to enable topical anesthesia. In Dentistry, topical anesthesia is performed prior to deep injection of local anesthesia. However, due (AU)
Local anesthetics (LA) are amphiphile compounds that interact with the sodium channel protein reversibly blocking the action potential of excitable membranes. The more potent the anesthetic (as for instance bupivacaine, which is the drug-of-choice for surgical procedures) the more toxic it is to the Central Nervous and Cardiovascular systems. Our research group has been working in the dev…
The topical anesthetics available in Dentistry do not allow painless local anesthesia, considering pain due to needle insertion and injection. The use of control release systems can improve local anesthetic efficacy. Lidocaine-prilocaine loaded poly(epsilon-caprolactone) nanocapsules has been shown adequate stability, high encapsulation efficiency and sustained release, becoming a promisi…
Local anesthesia is used in most dental procedures. However, its administration occurs parenterally, so local anesthesia is painful, generating fear, anxiety, stress in patients and consequently the interruption of dental treatment. Therefore, to minimize the discomfort caused by the injection, many dentists perform topical anesthesia prior to local anesthesia. However, many studies revea…
New therapeutic formulations must be tested for safety and efficacy. One of the essential steps is in vivo toxicity testing. In the case of products created for topical use in the oral cavity, the test considered the gold standard is called the "Oral Mucosa Irritation Test", performed in hamsters. For causing discomfort, pain and suffering in the animal some alternative methodologies are …
Oral mucositis is an inflammatory disease that manifests throughout the oral cavity and it can affect the pharynx, larynx, esophagus and other areas. It becomes necessary to discover new therapeutic alternatives since oral mucositis does not have a good treatment. The grape is considered one of the most beneficial fruit for health, as it has important pharmacological actions due to the pr…
Mucoadhesive drug delivery systems have been extensively investigated for the topical administration of drugs on mucosa, especially the oral mucosa. These systems offer the advantage of increasing the contact time of the drug with the buccal mucosa, which is highly vascularized, and thus, it can increase the drug bioavailability at the action site, avoiding the effects of first-pass hepat…
Local anesthesia is required for most dental procedures. However, due to its route of administration, local anesthesia is painful and can cause withdrawal of phobic patients and consequently, promote discontinuation of dental treatment, impairing their oral health. Thus, many dentists perform topical anesthesia prior to local anesthesia to minimize the discomfort of the injection. However…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 4 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 16 / 15 | Completed scholarships in Brazil |
| 24 / 22 | All research grants and scholarships |
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CV Lattes
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